Prolia can cause many serious side effects. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. This medication guide provides information about the Prolia brand of denosumab. * For more information on this side effect, see the Side effect focus section below. If you develop serious side effects while taking Prolia, call your doctor right away. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. The most common side effects of Prolia in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Heres a short list of some of the mild side effects that Prolia can cause. Do not stop, skip or delay taking Prolia without first talking with your doctor. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. But this isnt the case with Prolia. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Store in the original container away from heat and light. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Constipation was also reported as a side effect in females using Prolia for osteoporosis. This helps treat osteoporosis by improving bone mass and strengthening your bones. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. The Prolia is making my leg bones and jaw bones hurt. You are encouraged to report negative side effects of prescription drugs to the FDA. (2022). They can tell you more about benefits and risks of Prolia and Forteo. To learn more about this side effect, see Side effect specifics below. Serious infections may occur during treatment with Prolia. Some items may interact with your medicine. You will receive your Prolia injection from your healthcare provider at a their office or clinic. If youve already gone through menopause, your risk for bone loss is increased. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. And some of these side effects are more common with certain uses of Prolia. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. There arent any studies that have compared these two drugs to each other. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. You should receive your missed injection as soon as possible. (Vitamin D helps your body absorb calcium.) What are the possible side effects of Prolia? These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Youll likely have questions about your condition and treatment choices. NOTE: This medicine is only for you. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). What should be considered before taking Prolia? Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Although its rare, your doctor may give you the option to self-inject Prolia at home. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. No, Prolia isnt a bisphosphonate. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Your doctor can also advise you on symptoms of low calcium to look for. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. Continue reading, Prolia (denosumab) does increase bone density. For Prolia, talk to your pediatrician regarding the use of this medicine in children. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Prolia comes as a solution thats given as an injection under your skin. And some of these side effects are more common with certain uses of Prolia. Prolia is injected under the skin. Its important to tell your doctor if you have serious or ongoing side effects. There arent any reported interactions between Prolia and alcohol. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Do not become pregnant while taking this medicine or for 5 months after stopping it. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. If your levels are high, theyll typically recommend lifestyle changes and medication. Available for Android and iOS devices. Prolia may cause serious side effects. Theyll likely suggest other treatment options for your condition. Biosimilars usually cost less than brand-name drugs. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. (Chlorhexidine helps kill germs in your mouth.). They can suggest ways to help relieve these side effects. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. What Health Changes Should You Expect Postmenopause? Prolia can cause certain side effects, some of which are more common than others. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The lists below describe some of the more common side effects that Prolia may cause. Take only the amount of calcium and vitamin D that your doctor has prescribed. If youre pregnant or breastfeeding, or considering either, talk with your doctor. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. If your doctor says this is safe for you, youll be shown how to inject the medication. Prolia can also cause bones to not form correctly and reduced growth in a fetus. If you have low calcium levels, you should not take Prolia. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. The study uses data from the FDA. These factors include what your insurance plan covers. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. But it can increase your risk of serious health problems, such as heart attack. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. WebYou should take calcium and vitamin D as your doctor tells you to while you receive But weight gain may be a symptom of a side effect called peripheral edema. See what this means for you in the chart below. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Some reports may have incomplete information. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. generic drugs) are not considered. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. We comply with the HONcode standard for trustworthy health information. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Prolia is usually given once every 6 months. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. They also include any added costs of the drug being given by a healthcare professional. For information about the difference between sex and gender, see this article. You should talk with your doctor if you develop any mild side effects that concern you. Its not known if Prolia is safe or effective for use in children. For instance, if you have a health condition that causes excess calcium in Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for infection with Prolia may be higher if you have a weakened immune system. All subjects in the clinical trials of Prolia received 800mg of calcium and If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. This drug may decrease your body's ability to fight infection. Its important to practice good oral hygiene during Prolia treatment. These side effects may be temporary, lasting a few days or weeks. Tell your doctor if you become pregnant. Dosage of drugs is not considered in the study. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Vitamin D The body needs vitamin D to absorb calcium. Your doctor can help you decide which drug is better for your needs. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. These lists dont include all possible side effects. Youll receive 60 mg/mL of Prolia once every 6 months. Talk with your doctor about the best options for treating your condition. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. These effects are called interactions. How long will the side effects of Prolia last? Doing so will help to prevent dental problems. So be sure to tell your doctor about all your health conditions before taking Prolia. * Approximation only. Do not reuse a needle or syringe. you can take. Keep out of the reach of children and pets. They can help you decide whether the possible benefits for your condition outweigh your risks for serious side effects. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. High cholesterol levels can be a side effect of Prolia. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. * Sex and gender exist on spectrums. You might be interested in seeing how Prolia and the drug Boniva compare. Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. This may help to protect healthy cells from damage. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. This means your bones may be weaker than usual. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. This increases your risk for bone fractures. What is the most important information I should know about Prolia? Bone pain from Prolia may be most noticeable in your arms and legs. Prolia contains the active ingredient denosumab. Mild side effects can occur with Prolia use. Before you have any dental work done, tell your dentist you are receiving this medicine. (To learn more, see the Precautions for Prolia section below.). This can cause your weight to change and may explain any weight gain since starting Prolia treatment. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Most Medicare plans and other insurance plans cover Prolia. If you want to stop taking Prolia, tell your doctor. Please see Prolia full Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. But Prolia is given once every 6 months by a healthcare professional. These are not all the possible side effects of Prolia. Learn strategies you can use today. Prolia may be used off-label for RA, if you have a high risk for bone fractures. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. 2,4. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. Drug class: miscellaneous bone resorption inhibitors. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. You may need to have a dental exam before you begin treatment with Prolia. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. These are serious. To learn how Prolia and Tymlos are alike and different, see this comparison. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. This information is intended only for U.S. healthcare professionals. Its a, Forteos active ingredient is teriparatide. What should I know about Prolia vs. Evenity? People need calcium for bone health and other functions. What should I know about Prolia vs. Reclast? What are some frequently asked questions about Prolia? Prolia isnt known to cause any harmful interactions with alcohol. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. Use of the term female in this article refers to sex assigned at birth. Different individuals may respond to medication in different ways. Do not stop using this medicine without first talking to your doctor. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. Patients should not stop Prolia treatment without first consulting your Prolia is a RANKL inhibitor. Do not stop, skip or delay taking Prolia without first talking with your doctor. But theyre each effective in treating osteoporosis and preventing bone loss. If you miss a dose of Prolia, you should receive your injection as soon as you can. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Theyll discuss with you other treatments to help protect you from fractures and bone loss. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. For more information about how Prolia and Zometa compare with each other, see this article. Talk with your doctor if youd like to know about taking generic denosumab. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Coral calcium is also used in maxillofacial surgery and bone grafting. Discuss the foods you eat and the vitamins you take with your health care professional. may occur. Every 6 months youll get another dose of Prolia. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. The drug stays in your system and continues to slow bone breakdown over this period of time. There are no known interactions with Prolia and other medications, supplements, or other products. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. Be sure to read this information carefully each time. Protect from light and do not freeze. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Talk with them about your health and any concerns you have about Prolia and its effects. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. But its not clear whether this side effect occurred in clinical studies.
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